Towards the synthetic dragonfly

Synthetic Studies towards the Cadiolides

A novel laboratory synthesis of cadiolides was studied. Cadiolides are secondary metabolites from marine ascidians and tunicates, and they were found to have potent activity against Gram positive bacteria like Methycillin Resistant Staphylococcus Aureus (MRSA). Previous laboratory synthesis of Cadiolide B has been accomplished by 6 steps and with a 42% overall yield. However, this approach was ...

Towards Autonomous Synthetic Actors

This paper describes an animation approach with autonomous actors reacting to their environment and taking decisions based on perception systems, memory and reasoning. With such a system, we should be able to create simulations of situations such as virtual humans moving in a complex environment they may know and recognize, or playing ball games based on their visual and touching perception. In...

Towards a Synthetic Chloroplast

BACKGROUND The evolution of eukaryotic cells is widely agreed to have proceeded through a series of endosymbiotic events between larger cells and proteobacteria or cyanobacteria, leading to the formation of mitochondria or chloroplasts, respectively. Engineered endosymbiotic relationships between different species of cells are a valuable tool for synthetic biology, where engineered pathways bas...

Synthetic studies towards bottromycin

Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.

Towards Synthetic Peptide Ligation